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Research highlights see: BNMRZ Press Releases

* 6th April 2023: Nobel prize laureate Ada Yonath visited the TUM Chemistry department

* BNMRZ is featured in TUM Image brochure, "The Power of Molecules", p. 50/51 (en | de)

* Welt Chagas Tag: Fortschritte bei einer vergessenen Krankheit: Deutschlandfunk: Web - MP3

* TUM "Faszination Forschung" featuring research at BNMRZ: How proteins work - (PDF download: DE EN)

* A virtual tour through the BNMRZ (video)

* Research at BNMRZ

Developing new therapies to fight parasite diseases (Sleeping Sickness; Chagas)

* Forschung am BNMRZ:

Entwicklung neuer Medikamente gegen Parasitenerkrankungen
(Schlafkrankheit; Chagas)

Research at BNMRZ focuses on the development and application of advanced NMR methods for studying the structure, dynamics and molecular interactions of biological macromolecules, computational approaches for integrative structural biology, structured-based drug discovery, pulse sequence and methods development for solution and solid-state NMR spectroscopy and magnetic resonance imaging.

[Disclaimer: material deposited here is available without warranty, pulse sequence implementation may need to be adapted depending on your spectrometer]

A more complete list of solution state experiments can be found on the BNMRZ Wiki (internal use only)

Experiment	Pulse program / dataset	Explanation	Reference
BUSS decoupling	Download BUSS decoupling shape	Decoupling shape for Bruker spectrometers, see supplement of Angew Chem paper for details	Schilling F, Warner LR, Gershenzon NI, Skinner TE, Sattler M, Glaser SJ. Next-Generation Heteronuclear Decoupling for High-Field Biomolecular NMR Spectroscopy. (2014) Angew Chem Int Ed Engl. 53, 4475–4479. doi: 10.1002/anie.201400178 [Pubmed].
(lr) HNN-COSY	Download	J(N-N) correlation in isotope-labeled RNA pulse program and Bruker AvanceIII dataset	(1) Dallmann, A.; Sattler, M. Detection of Hydrogen Bonds in Dynamic Regions of RNA by NMR Spectroscopy. Curr. Protoc. Nucleic Acid Chem. 2014, 2014, 7.22.1-7.22.19. https://doi.org/10.1002/0471142700.nc0722s59. (2) Dallmann, A.; Simon, B.; Duszczyk, M. M.; Kooshapur, H.; Pardi, A.; Bermel, W.; Sattler, M. Efficient Detection of Hydrogen Bonds in Dynamic Regions of RNA by Sensitivity-Optimized NMR Pulse Sequences. Angew. Chemie Int. Ed. 2013, 52 (40), 10487–10490. https://doi.org/10.1002/anie.201304391.
Py H(CC)NN-COSY	Download	J(N-N) correlation in isotope-labeled RNA pulse program and Bruker AvanceIII dataset]	see references above
DE HCCH-TOCSY	Download	E/AE (t₁ & t₂) => 2x sensitivity enhanced	Sattler M, Schwendinger MG, Schleucher J, and Griesinger C Novel strategies for sensitivity enhancement in heteronuclear multi-dimensional NMR experiments employing pulsed field gradients. (1995) J Biomol NMR, 6:11-22 (1995) [Pubmed] [Springer Link]
CDCA(NCO)CAHA	Download	E/AE, 2×¹³C CT periods with C^a/C^d and C^a selective pulses; for assignment of proline stretches	Bottomley MJ, Macias MJ, Liu Z, Sattler M. A novel NMR experiment for the sequential assignment of proline residues and proline stretches in 13C/ 15N labeled proteins. (1999) J. Biomol. NMR 13, 381-385. [Pubmed]
Adenine HCCH-COSY	Download	Long-range HCCH correlation in adenine bases	Simon B, Zanier K, Sattler M A TROSY relayed HCCH-COSY experiment for correlating adenine H2/H8 resonances in uniformly 13C-labeled RNA molecules (2001) J Biomol NMR, 20:173-176 [Pubmed] [Springer Link]
2D w2-filtered NOESY	noexfcng	for D2O samples; double-filter for ¹³C^ali, single filter for ¹⁵N and ¹³C^arom	Sattler M., Schleucher J., and Griesinger C. Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients. (1999) Prog. NMR Spectrosc. 34, 93-158.