EMBO
Practical Course:
Structure,
dynamics
and
function
of
biomacromolecules
by solution NMR
The
intention of
the course is to
provide practical training in
important aspects of using solution
state
NMR spectroscopy for studying the
structure, dynamics and function of
biomolecular macromolecules. The
emphasis will be on setting up
experiments on the spectrometer
(optimizing parameters, pulse
programs), on processing and analyzing
the NMR data and on structure
calculations in a hands-on fashion.
It
is
impossible
to teach all the necessary
theoretical background of modern NMR
experiments in a few days.
Therefore, the course is aimed at PhD
students and postdocs who have
some working knowledge of NMR theory,
i.e. product operator formalism,
and who understand the basic
principles of NMR pulse sequences.
Possible candidates should have the
level of knowledge of students that
have participated in a past "Advanced
NMR" EMBO lecture course on NMR
theory organized by Boelens, Oschkinat
and Griesinger.
Organizers
Stephan Grzesiek (Biozentrum Basel)
Michael
Nilges
(Institut Pasteur, Paris)
Michael
Sattler (TU
München, Helmholtz Zentrum München)
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Sponsors:
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Location
BNMRZ,
Department Chemie, TU München; Garching
(Germany)
Date
Jul 29 -
Aug 5,
2011
Programme Final
Programme
Lectures
Lecture
notes and practical manuals
Login details have been
provided to participants.
Literature
Recommendations
from
the instructors (request from Round
Table)
Photos
Please send
any (digital) photos you may
have for posting here to Gerd or
Michael.
A
first selection of pictures from
participants can be found here.
To be
updated!
Registration EMBO (registration)
(Registration is
closed)
There
will
be
a fee of 250
EUR for accepted participants, which
covers lodging, food,
workshop dinner etc.
Accepted participants
have been notified.
Contact
Michael
Sattler sattler@helmholtz-muenchen.de
Subway
schedule
Hotel --> TUM
TUM-->
Hotel
Hotel
All participants and instructors will be
staying in the Hotel
Ludwig in Garching.
The hotel is only one stop (by
subway U6) from the Department
Chemie at the Garching
campus of TUM, where the course is held.
Travel
How to get to the Bavarian NMR Center
Please
follow
the directions to
the BNMRZ at the TUM Garching
campus.
Signs
with the
EMBO logo will direct you
to the seminar room where the course
will start on Fri July 29, 13:30
in Room 53301 (yellow cross).
Travel
grants Can be
applied for to support
participants from
certain countries (eligibility see
here).
Accepted participants have been
informed).
Instructors
Martin
Blackledge
(IBS Grenoble)
Bernhard Brutscher
(IBS Grenoble)
Frank Delaglio
(NIH, Bethesda)
Steffen Glaser (TU
München)
Peter Güntert (U
Frankfurt)
Christian
Griesinger (MPI Göttingen)
Stephan Grzesiek
(Biozentrum Basel)
Helen Mott (U
Cambridge)
Daniel Nietlispach
(U Cambridge)
Michael Nilges
(Institut Pasteur, Paris)
Roland Riek (ETH
Zurich)
Michael Sattler (TU
München, Helmholtz Zentrum München)
Harald Schwalbe (U
Frankfurt)
Bernd Simon (EMBL
Heidelberg)
Nico Tjandra (NIH,
Bethesda)
Geerten Vuister (U
Leicester)
Tutors
Benjamin
Bardiaux
(FMP Berlin/Institut Pasteur, Paris)
Sonja Dames (TU München)
Gerd Gemmecker
(Bavarian NMR Centre, TU
München/Helmholtz Zentrum München)
Rainer Haessner
(Bavarian NMR Centre, TU München/Helmholtz
Zentrum
München)
Henry Jonker (U
Frankfurt)
Therese Malliavin (Institut Pasteur,
Paris)
Topics
• Pulse
sequences: theory,
design, practical set-up and use
•
Multidimensional
data processing and data analysis
• Relaxation:
theory,
experiments, data analysis
• Residual
dipolar
and J-couplings: theory, experiments,
data analysis
•
Structure
calculation and validation: proteins
and RNA
•
Protein-ligand
interactions
•
High molecular
weight systems, TROSY, CRINEPT, etc.
•
Advanced/fast
data acquisitionand processing
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