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Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction.
Frontiers in cell and developmental biology, Vol. 9, 737159
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Lopez A, Dahiya V, Delhommel F, Freiburger L, Stehle R, Asami S, Rutz D, Blair L, Buchner J, Sattler M (2021)
Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.
Science advances, Issue 51, Vol. 7, eabl7295
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Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy.
Frontiers in immunology, Vol. 12, 750478
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Phosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble.
Nature communications, Issue 1, Vol. 12, 6697
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A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes.
Nature communications, Issue 1, Vol. 12, 6515
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Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling.
Cell reports, Issue 6, Vol. 37, 109989
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Maximizing efficiency of dipolar recoupling in solid-state NMR using optimal control sequences.
Science advances, Issue 42, Vol. 7, eabj5913
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PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.
EMBO reports, Issue 12, Vol. 22, e53007
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Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents.
Journal of chemical information and modeling, Issue 10, Vol. 61, 5256-5268
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Seitz C, Eisenreich W, Huber C (2021)
The Abiotic Formation of Pyrrole under Volcanic, Hydrothermal Conditions-An Initial Step towards Life's First Breath?
Life (Basel, Switzerland), Issue 9, Vol. 11
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Sperl LE, Rührnößl F, Schiller A, Haslbeck M, Hagn F (2021)
High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.
The EMBO journal, Issue 20, Vol. 40, e107159
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Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold.
International journal of pharmaceutics, Vol. 607, 121043
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SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.
Nature communications, Issue 1, Vol. 12, 4910
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Reyes Romero A, Lunev S, Popowicz GM, Calderone V, Gentili M, Sattler M, Plewka J, Taube M, Kozak M, Holak TA, Dömling ASS, Groves MR (2021)
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
Communications biology, Issue 1, Vol. 4, 949
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Reif B, Ashbrook SE, Emsley L, Hong M (2021)
Solid-state NMR spectroscopy.
Nature reviews. Methods primers, Vol. 1
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Protease resistance of ex vivo amyloid fibrils implies the proteolytic selection of disease-associated fibril morphologies.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, Issue 4, Vol. 28, 243-251
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Molecular insights on CALX-CBD12 interdomain dynamics from MD simulations, RDCs, and SAXS.
Biophysical journal, Issue 17, Vol. 120, 3664-3675
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Baur S, Frank O, Hausladen H, Hückelhoven R, Hofmann T, Eisenreich W, Dawid C (2021)
Biosynthesis of α-solanine and α-chaconine in potato leaves (Solanum tuberosum L.) - A 13CO2 study.
Food chemistry, Vol. 365, 130461
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Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia.
Journal of enzyme inhibition and medicinal chemistry, Issue 1, Vol. 36, 1267-1281
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Geldschläger O, Bosch D, Glaser S, Henning A (2021)
Local excitation universal parallel transmit pulses at 9.4T.
Magnetic resonance in medicine, Issue 5, Vol. 86, 2589-2603
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Steiner TM, Lettl C, Schindele F, Goebel W, Haas R, Fischer W, Eisenreich W (2021)
Substrate usage determines carbon flux via the citrate cycle in Helicobacter pylori.
Molecular microbiology, Issue 3, Vol. 116, 841-860
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Sperl LE, Hagn F (2021)
NMR Structural and Biophysical Analysis of the Disease-Linked Inner Mitochondrial Membrane Protein MPV17.
Journal of molecular biology, Issue 15, Vol. 433, 167098
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Feuerecker B, Biechl P, Veltkamp C, Saur D, Eisenreich W (2021)
Metabolic Response of Pancreatic Carcinoma Cells under Treatment with Dichloroacetate.
Metabolites, Issue 6, Vol. 11
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Martikyan V, Beluffi C, Glaser SJ, Delsuc MA, Sugny D (2021)
Application of Optimal Control Theory to Fourier Transform Ion Cyclotron Resonance.
Molecules (Basel, Switzerland), Issue 10, Vol. 26
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Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Nature communications, Issue 1, Vol. 12, 2999
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Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U (2021)
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.
EMBO reports, Issue 6, Vol. 22, e49568
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Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors.
Photoacoustics, Vol. 22, 100263
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Gaussmann S, Gopalswamy M, Eberhardt M, Reuter M, Zou P, Schliebs W, Erdmann R, Sattler M (2021)
Membrane Interactions of the Peroxisomal Proteins PEX5 and PEX14.
Frontiers in cell and developmental biology, Vol. 9, 651449
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Kunze M, Steiner T, Chen F, Huber C, Rydzewski K, Stämmler M, Heuner K, Eisenreich W (2021)
Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii.
International journal of medical microbiology : IJMM, Issue 4, Vol. 311, 151504
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Steffens L, Pettinato E, Steiner TM, Mall A, König S, Eisenreich W, Berg IA (2021)
High CO2 levels drive the TCA cycle backwards towards autotrophy.
Nature, Issue 7856, Vol. 592, 784-788
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Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Journal of medicinal chemistry, Issue 8, Vol. 64, 4623-4661
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Munshaw S, Bruche S, Redpath AN, Jones A, Patel J, Dubé KN, Lee R, Hester SS, Davies R, Neal G, Handa A, Sattler M, Fischer R, Channon KM, Smart N (2021)
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
The Journal of clinical investigation, Issue 10, Vol. 131, e127884
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Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy.
Advanced healthcare materials, Issue 9, Vol. 10, e2002115
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Feuerecker B, Biechl P, Seidl C, Bruchertseifer F, Morgenstern A, Schwaiger M, Eisenreich W (2021)
Diverse metabolic response of cancer cells treated with a 213Bi-anti-EGFR-immunoconjugate.
Scientific reports, Issue 1, Vol. 11, 6227
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Radziej S, Scherb-Forster J, Schlicht C, Eisenreich W (2021)
Fast Identification of Food Thickeners by Nontargeted NMR-Spectroscopy.
Journal of agricultural and food chemistry, Issue 12, Vol. 69, 3761-3775
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Geisberger T, Sobotta J, Eisenreich W, Huber C (2021)
Formation of Thiophene under Simulated Volcanic Hydrothermal Conditions on Earth-Implications for Early Life on Extraterrestrial Planets?
Life (Basel, Switzerland), Issue 2, Vol. 11
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A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins.
The EMBO journal, Issue 8, Vol. 40, e103811
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Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Nature structural & molecular biology, Issue 3, Vol. 28, 258-267
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FARS1-related disorders caused by bi-allelic mutations in cytosolic phenylalanyl-tRNA synthetase genes: Look beyond the lungs!
Clinical genetics, Issue 6, Vol. 99, 789-801
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Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis.
Nature microbiology, Issue 4, Vol. 6, 533
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Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.
Nature communications, Issue 1, Vol. 12, 828
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NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function.
Cell, Issue 3, Vol. 184, 577-595
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Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility.
Journal of molecular biology, Issue 5, Vol. 433, 166765
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Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation.
iScience, Issue 1, Vol. 24, 101940
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Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Nature chemical biology, Issue 3, Vol. 17, 272-279
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López A, Elimelech AR, Klimm K, Sattler M (2021)
The Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90.
Chembiochem : a European journal of chemical biology, Issue 6, Vol. 22, 1084-1092
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Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou P (2021)
Albumin-binding domain extends half-life of glucagon-like peptide-1.
European journal of pharmacology, Vol. 890, 173650
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Pradhan T, Annamalai K, Sarkar R, Hegenbart U, Schönland S, Fändrich M, Reif B (2021)
Solid state NMR assignments of a human λ-III immunoglobulin light chain amyloid fibril.
Biomolecular NMR assignments, Issue 1, Vol. 15, 9-16
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Probing the Conformation States of Neurotensin Receptor 1 Variants by NMR Site-Directed Methyl Labeling.
Chembiochem : a European journal of chemical biology, Issue 1, Vol. 22, 139-146
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