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News

BNMRZ research is featured in the "Abendschau" (Bavarian Television) on 22 Feb 2026.

The Bavarian NMR Center (BNMRZ), a joint research infrastructure of Helmholtz Munich and the Technical University of Munich (TUM), has joined the newly established German Centre of Instruct-ERIC. See also the official Helmholtz Munich press release.

Read more: News

[Disclaimer: material deposited here is available without warranty, pulse sequence implementation may need to be adapted depending on your spectrometer]

A more complete list of solution state experiments can be found on the BNMRZ Wiki (internal use only)

Experiment

Pulse program / dataset

Explanation

Reference

BUSS decoupling

Download BUSS decoupling shape

Decoupling shape for Bruker spectrometers, see supplement of Angew Chem paper for details

Schilling F, Warner LR, Gershenzon NI, Skinner TE, Sattler M, Glaser SJ.
Next-Generation Heteronuclear Decoupling for High-Field Biomolecular NMR Spectroscopy.
(2014) Angew Chem Int Ed Engl. 53, 4475–4479.
doi: 10.1002/anie.201400178 [Pubmed].

(lr) HNN-COSY

Download

J(N-N) correlation in isotope-labeled RNA

pulse program and Bruker AvanceIII dataset

(1) Dallmann, A.; Sattler, M. Detection of Hydrogen Bonds in Dynamic Regions of RNA by NMR Spectroscopy. Curr. Protoc. Nucleic Acid Chem. 2014, 2014, 7.22.1-7.22.19. https://doi.org/10.1002/0471142700.nc0722s59.

(2) Dallmann, A.; Simon, B.; Duszczyk, M. M.; Kooshapur, H.; Pardi, A.; Bermel, W.; Sattler, M. Efficient Detection of Hydrogen Bonds in Dynamic Regions of RNA by Sensitivity-Optimized NMR Pulse Sequences. Angew. Chemie Int. Ed. 2013, 52 (40), 10487–10490. https://doi.org/10.1002/anie.201304391.

Py H(CC)NN-COSY

Download

J(N-N) correlation in isotope-labeled RNA

pulse program and Bruker AvanceIII dataset]

see references above

DE HCCH-TOCSY

Download E/AE (t1 & t2) => 2x sensitivity enhanced


Sattler M, Schwendinger MG, Schleucher J, and Griesinger C
Novel strategies for sensitivity enhancement in heteronuclear multi-dimensional NMR experiments employing pulsed field gradients.
(1995) J Biomol NMR, 6:11-22 (1995)
[Pubmed] [Springer Link]

CDCA(NCO)CAHA Download E/AE, 2×13C CT periods with Ca/Cd and Ca selective pulses; for assignment of proline stretches
Bottomley MJ, Macias MJ, Liu Z, Sattler M.
A novel NMR experiment for the sequential assignment of proline residues and proline stretches in 13C/ 15N labeled proteins.
(1999) J. Biomol. NMR 13, 381-385.
[Pubmed]
Adenine HCCH-COSY Download Long-range HCCH correlation in adenine bases
Simon B, Zanier K, Sattler M
A TROSY relayed HCCH-COSY experiment for correlating adenine H2/H8 resonances in uniformly 13C-labeled RNA molecules

(2001) J Biomol NMR, 20:173-176
[Pubmed] [Springer Link]
2D w2-filtered NOESY noexfcng for D2O samples; double-filter for 13Cali, single filter for 15N and 13Carom
Sattler M., Schleucher J., and Griesinger C.
Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients.
(1999) Prog. NMR Spectrosc. 34, 93-158.

 

 

Research at BNMRZ focuses on the development and application of advanced NMR methods for studying the structure, dynamics and molecular interactions of biological macromolecules, computational approaches for integrative structural biology, structured-based drug discovery, pulse sequence and methods development for solution and solid-state NMR spectroscopy and magnetic resonance imaging.

Helmholtz Munich

Helmholtz Munich - Molecular Targets and Therapeutics Center (MTTC)

Helmholtz Munich - Institute of Structural Biology (STB)

TUM School of Natural Sciences

TUM Department of Biosciences

Center for Functional Protein Assemblies (CPA)

Munich Institute of Biomedical Engineering (MIBE)

Cluster for Nucleid Acid Therapeutics Munich

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Lectures and Seminars

BNMRZ
Dr. Cameron Mackereth
Inserm U1212 / Univ. Bordeaux
ARNA Laboratory
Mon May 04, 2026, 15:00

BNMRZ Seminar room
Unexpected DNA structure in aptamer-based recognition of small molecules

News

BNMRZ research is featured in the "Abendschau" (Bavarian Television) on 22 Feb 2026.

The Bavarian NMR Center (BNMRZ), a joint research infrastructure of Helmholtz Munich and the Technical University of Munich (TUM), has joined the newly established German Centre of Instruct-ERIC. See also the official Helmholtz Munich press release.

Conferences and Workshops

EMBO Practical Course: Structural dynamics, interactions and function of biological macromolecules by NMR
July 24-31, 2026
BNMRZ, Garching

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