Highlights & press releases

Unleashing splicing to understand biology and eventually tackle ‘untreatable’ diseases
(2023) ERC Synergy grant UNLEASH, Sattler, 07.06.2023

Identification of a key factor for splicing long introns
Mutations in FUBP1 cause defective gene regulation in glioma cells
(2023) Mol Cell, Sattler, 21.08.2023
Insights into the Aggregation Mechanism of an antibody light chain domain in AL amyloidosis
Transitions between solution to solids
(2023) Nature Commun, Reif, 23.06.2023
Helping plants make better use of sunlight
Structural basis of metabolite transport across the outer envelope membrane
(2023) Nature Struc Mol Biol, Hagn, 08.05.2023
Nobel prize laureate Ada Yonath visited TUM
(2023) hosted by BNMRZ 06.04.2023
  Dynamic RNA structure is modulated by RNA binding proteins to control splicing
Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1.
(2022) Science Adv., Sattler, 2022
  Hope in the Fight against Parasites
Drug discovery
(2022) Helmholtz News Room, Sattler

Advances in visualizing large quantum states
Fast computation of spherical phase-space functions of quantum many-body states.
(2021) Phys. Rev. A, Glaser, 01.02.2021
  Optimum Sensitivity with Optimal Control
Optimal Control pulse schemes for a broad range of MAS frequencies
(2021) Science Adv., Reif, Glaser, 13.10.2021
  Role of conformational dynamics in Hsp90 chaperone function
Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.
(2021) Science Adv., Sattler, 2021
Activation of pore formation by pro-apoptotic Bak
Large conformational changes of Bak at the membrane surface
(2021) EMBO J., Hagn, 15.09.2021
  A small-tip angle approximation in the toggling frame makes it possible to analytically design robust broadband NMR pulses.
(2021) Phys. Rev. A, Glaser 2021
  Visualization arbitrary quantum states - based on a novel symmetry-adapted decomposition of tensor operators, explicit matrix representations were derived for the visualization arbitrary quantum states for systems consisting of up to six coupled spins.
(2020) J. Phys. A: Math. Theor., Glaser 2020
  Erwin Schrödinger Prize to Michael Sattler and colleagues
(2020) Erwin Schrödinger Preis, Sattler 12.10.2020
Recognition mechanism of g-secretase revealed for the Alzheimer risk factor TREM2
Processing is dependent on the structural integrity of the transmembrane helix
(2020) EMBO J., Hagn, 24.08.2020
Interaction Surface Mimic Inhibitors
Mode of action of ISM inhibitors uncovered
(2020) Angewandte Chemie, Reif, 27.03.2020
  Quality control in immune communication
Chaperones detect immature signaling molecules in the immune system

(2019) Nature Commun, Sattler, 20.09.2019
  Newly constructed Bavarian NMR Center opens at Technical University of Munich
World's highest performance Nuclear Magnetic Resonance spectrometer for biomedical research
(2018) TUM press release, BNMRZ, 19.10.2018
  New Insights into the Maturation of miRNAs
Elucidating the maturation mechanism of a cancer-causing microRNA
(2018) Nature Commun, Sattler, 03.07.2018)
  Breakthrough for peptide medication
The "Holy Grail" of peptide chemistry: making peptide active agents available orally (Angewandte Chemie 2017, Kessler, 21.02.2018)
  New insights into the tumor metabolism
Medical imaging: new biosensor zymonic acid shows changes in pH value (Nature Commun 2017, Glaser, Schilling, 11.05.2017)
  New therapeutic strategy against sleeping sickness
Structural Biology develops active agent that blocks trypanosomes (Science 2017, Sattler, 31.03.2017)
  Shaping up to make the cut
RNA-based gene regulation with dynamic proteins (PNAS 2016, Sattler, 03.11.2016)
  Richtfest für Neubau des Bayerischen Kernresonanz-Zentrums
(BNMRZ, 29.05.2016)
  Alzheimer's disease: new field of application for versatile helper
Molecular mechanisms of small heat shock proteins (Nature Struc Mol Biol, Reif, 13.10.2015)
  World-class nuclear magnetic resonance center
TUM defines a new dimension for biomedical research, (Grundsteinlegung BNMRZ-Neubau, 16.11.2015)
  Visualizing the “matrix”
App provides insight into the quantum world of coupled nuclear spins (Phys. Rev. A 2015, Glaser, 03.06.2015)
  Doubled productivity
New mechanism in gene regulation revealed (Nature 2014, Sattler, 08.09.2014)
  Molecular mechanisms underlying the prevention of autoimmunity by Roquin revealed
(Nature Struc Mol Biol, Sattler, 14.07.2014)
  Bayerisches NMR-Zentrum von Weltrang
Wissenschaftsrat bewilligt Forschungsneubau in Garching (BNMRZ, 26.04.2013)